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Distinct Pharmacological Effects of Inhibitors of Signal Peptide Peptidase and γ-Secretase
Signal peptide peptidase (SPP) and γ-secretase are intramembrane aspartyl proteases that bear similar active site motifs but with opposite membrane topologies. Both proteases are inhibited by the same aspartyl protease transition-state analogue inhibitors, further evidence that these two enzymes hav...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586255/ https://ncbi.nlm.nih.gov/pubmed/18829463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805670200 |
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