Distinct Pharmacological Effects of Inhibitors of Signal Peptide Peptidase and γ-Secretase

Signal peptide peptidase (SPP) and γ-secretase are intramembrane aspartyl proteases that bear similar active site motifs but with opposite membrane topologies. Both proteases are inhibited by the same aspartyl protease transition-state analogue inhibitors, further evidence that these two enzymes hav...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sato, Toru, Ananda, Kuppanna, Cheng, Cathy I., Suh, Eric J., Narayanan, Saravanakumar, Wolfe, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Enzyme Catalysis and Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586255/
https://ncbi.nlm.nih.gov/pubmed/18829463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805670200
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky