The non-enantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with l- and d-nucleosides

Lignende værker

• Elucidation of Different Binding Modes of Purine Nucleosides to Human Deoxycytidine Kinase
  af: Sabini, Elisabetta, et al.
  Udgivet: (2008)
• Structural basis for activation of the therapeutic l-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase
  af: Sabini, Elisabetta, et al.
  Udgivet: (2007)
• Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase
  af: Hazra, Saugata, et al.
  Udgivet: (2009)
• Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release
  af: Hazra, Saugata, et al.
  Udgivet: (2011)
• The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogs
  af: Hazra, Saugata, et al.
  Udgivet: (2010)