Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release

Podobné jednotky

• Elucidation of Different Binding Modes of Purine Nucleosides to Human Deoxycytidine Kinase
  Autor: Sabini, Elisabetta, a další
  Vydáno: (2008)
• Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogs
  Autor: Hazra, Saugata, a další
  Vydáno: (2010)
• Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues
  Autor: McSorley, Theresa, a další
  Vydáno: (2008)
• The non-enantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with l- and d-nucleosides
  Autor: Sabini, Elisabetta, a další
  Vydáno: (2007)
• The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogs
  Autor: Hazra, Saugata, a další
  Vydáno: (2010)