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The non-enantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with l- and d-nucleosides

Biological molecules are predominantly enantioselective. Yet, currently two nucleoside analog prodrugs (3TC and FTC) with opposite chirality to physiological nucleosides are clinically approved for the treatment of HIV infections. These prodrugs require conversion to their tri-phosphorylated forms t...

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Bibliografische gegevens
Hoofdauteurs: Sabini, Elisabetta, Hazra, Saugata, Konrad, Manfred, Lavie, Arnon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586175/
https://ncbi.nlm.nih.gov/pubmed/17530837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0700215
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