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The non-enantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with l- and d-nucleosides
Biological molecules are predominantly enantioselective. Yet, currently two nucleoside analog prodrugs (3TC and FTC) with opposite chirality to physiological nucleosides are clinically approved for the treatment of HIV infections. These prodrugs require conversion to their tri-phosphorylated forms t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2586175/ https://ncbi.nlm.nih.gov/pubmed/17530837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0700215 |
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