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Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase
Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1). Whereas TK1 is only responsible for thymidine phosphorylation, dCK is capable of converting dC, dA, and dG into their monophosphate forms. Using structural data on dCK we p...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701478/ https://ncbi.nlm.nih.gov/pubmed/19159229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802062w |
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