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Elucidation of Different Binding Modes of Purine Nucleosides to Human Deoxycytidine Kinase
Purine nucleoside analogues of medicinal importance, such as cladribine, require phosphorylation by deoxycytidine kinase (dCK) for pharmacological activity. Structural studies of ternary complexes of human dCK show that the enzyme conformation adjusts to the different hydrogen-bonding properties bet...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636677/ https://ncbi.nlm.nih.gov/pubmed/18570408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800134t |
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