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Elucidation of Different Binding Modes of Purine Nucleosides to Human Deoxycytidine Kinase

Purine nucleoside analogues of medicinal importance, such as cladribine, require phosphorylation by deoxycytidine kinase (dCK) for pharmacological activity. Structural studies of ternary complexes of human dCK show that the enzyme conformation adjusts to the different hydrogen-bonding properties bet...

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書目詳細資料
Main Authors: Sabini, Elisabetta, Hazra, Saugata, Konrad, Manfred, Lavie, Arnon
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636677/
https://ncbi.nlm.nih.gov/pubmed/18570408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800134t
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