Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections

Many Gram-positive bacteria covalently tether their surface adhesins to the cell wall peptidoglycan. We find that surface proteins of Staphylococcus aureus are linked to the cell wall by sortase, an enzyme that cleaves polypeptides at a conserved LPXTG motif. S. aureus mutants lacking sortase fail t...

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Bibliographic Details
Main Authors: Mazmanian, Sarkis K., Liu, Gwen, Jensen, Eric R., Lenoy, Eileen, Schneewind, Olaf
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC25859/
https://ncbi.nlm.nih.gov/pubmed/10805806
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