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Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections

Many Gram-positive bacteria covalently tether their surface adhesins to the cell wall peptidoglycan. We find that surface proteins of Staphylococcus aureus are linked to the cell wall by sortase, an enzyme that cleaves polypeptides at a conserved LPXTG motif. S. aureus mutants lacking sortase fail t...

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Bibliografski detalji
Glavni autori: Mazmanian, Sarkis K., Liu, Gwen, Jensen, Eric R., Lenoy, Eileen, Schneewind, Olaf
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC25859/
https://ncbi.nlm.nih.gov/pubmed/10805806
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