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B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
CD45 and Fas regulate tyrosine phosphorylation and apoptotic signaling pathways, respectively. Mutation of an inhibitory wedge motif in CD45 (E613R) results in hyperresponsive thymocytes and B cells on the C57BL/6 background, but no overt autoimmunity, whereas Fas deletion results in a mild autoimmu...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585841/ https://ncbi.nlm.nih.gov/pubmed/19001138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081204 |
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