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The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity
CD45 is a receptor-like tyrosine phosphatase that positively regulates BCR signaling by dephosphorylating the inhibitory tyrosine of the Src family kinases (SFKs). We have previously shown that a single point mutation, E613R, introduced into the cytoplasmic membrane-proximal ‘wedge’ domain of CD45 i...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593789/ https://ncbi.nlm.nih.gov/pubmed/23396948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202928 |
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