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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
Pep and CD45 are tyrosine phosphatases whose targets include the Src-family kinases, critical mediators of antigen receptor signaling. A polymorphism in PTPN22, the gene that encodes the human Pep ortholog Lyp, confers susceptibility to multiple human autoimmune diseases in the context of complex ge...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765978/ https://ncbi.nlm.nih.gov/pubmed/19299707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803317 |
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