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PTPN22 in autoimmunity: different cell and different way
The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang et al. (2013) show that in myeloid cells PTPN22 potentiates TLR-induced type I IFN production and that autoimmunity-associated allele PTPN22W encodes a reduced-function variant.
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| Formato: | Artigo |
| Idioma: | Inglês |
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2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3785409/ https://ncbi.nlm.nih.gov/pubmed/23890067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.007 |
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