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PTPN22 in autoimmunity: different cell and different way
The tyrosine phosphatase PTPN22 regulates T cell receptor signaling. In this issue of Immunity, Wang et al. (2013) show that in myeloid cells PTPN22 potentiates TLR-induced type I IFN production and that autoimmunity-associated allele PTPN22W encodes a reduced-function variant.
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3785409/ https://ncbi.nlm.nih.gov/pubmed/23890067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.007 |
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