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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
Pep and CD45 are tyrosine phosphatases whose targets include the Src-family kinases, critical mediators of antigen receptor signaling. A polymorphism in PTPN22, the gene that encodes the human Pep ortholog Lyp, confers susceptibility to multiple human autoimmune diseases in the context of complex ge...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765978/ https://ncbi.nlm.nih.gov/pubmed/19299707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803317 |
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