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Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production

CD45, a protein tyrosine phosphatase that regulates Src family kinases, is important for regulating T cell and B cell receptor signaling; however, little is known about how CD45 regulates immunoreceptor tyrosine-based activation motif (ITAM)-dependent natural killer (NK) cell receptor signaling and...

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Detalhes bibliográficos
Main Authors: Hesslein, David G. T., Takaki, Rayna, Hermiston, Michelle L., Weiss, Arthur, Lanier, Lewis L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459010/
https://ncbi.nlm.nih.gov/pubmed/16627620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601851103
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