A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity

Hem1 (Hematopoietic protein 1) is a hematopoietic cell-specific member of the Hem family of cytoplasmic adaptor proteins. Orthologues of Hem1 in Dictyostelium discoideum, Drosophila melanogaster, and Caenorhabditis elegans are essential for cytoskeletal reorganization, embryonic cell migration, and...

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Autors principals: Park, Heon, Staehling-Hampton, Karen, Appleby, Mark W., Brunkow, Mary E., Habib, Tania, Zhang, Yi, Ramsdell, Fred, Liggitt, H. Denny, Freie, Brian, Tsang, Mark, Carlson, George, Friend, Sherree, Frevert, Charles, Iritani, Brian M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585840/
https://ncbi.nlm.nih.gov/pubmed/19015308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080340
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