Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation

Birt-Hogg-Dube’ Syndrome (BHDS) is a rare genetic disorder in humans characterized by skin hamartomas, lung cysts, pneumothorax, and increased risk of renal tumors. BHDS is caused by mutations in the BHD gene, which encodes for Folliculin, a cytoplasmic adapter protein that binds to Folliculin inter...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Centini, Ryan, Tsang, Mark, Iwata, Terri, Park, Heon, Delrow, Jeffrey, Margineantu, Daciana, Iritani, Brandon M., Gu, Haiwei, Liggitt, H. Denny, Kang, Janella, Kang, Lim, Hockenbery, David M., Raftery, Daniel, Iritani, Brian M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999084/
https://ncbi.nlm.nih.gov/pubmed/29897930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197973
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