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Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development
The coordination of nutrient and energy availability with cell growth and division is essential for proper immune cell development and function. Using a chemical mutagenesis strategy in mice, we identified a pedigree that has a complete block in B cell development at the pre-B cell stage due to a de...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361584/ https://ncbi.nlm.nih.gov/pubmed/22608497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.02.019 |
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