Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism

Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that coordinates nutrient and growth factor availability with cellular growth, division, and differentiation. Studies examining the roles of mTOR signaling in immune function revealed critical roles for mTOR in regulating T cell dif...

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Detalles Bibliográficos
Publicado en:J Immunol
Main Authors: Iwata, Terri N., Ramírez, Julita A., Tsang, Mark, Park, Heon, Margineantu, Daciana H., Hockenbery, David M., Iritani, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado: AAI 2016
Assuntos:
Immune System Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009877/
https://ncbi.nlm.nih.gov/pubmed/27521345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600492
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