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An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor

We have developed a nanoparticle formulation [liposomes-protamine-hyaluronic acid nanoparticle (LPH-NP)] for systemically delivering siRNA into the tumor. The LPH-NP was prepared in a self-assembling process. Briefly, protamine and a mixture of siRNA and hyaluronic acid were mixed to prepare a negat...

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Bibliografiske detaljer
Main Authors: Chono, Sumio, Li, Shyh-Dar, Conwell, Christine C., Huang, Leaf
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585496/
https://ncbi.nlm.nih.gov/pubmed/18674578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.07.006
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