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Efficient Gene Silencing in Metastatic Tumor by siRNA Formulated in Surface-modified Nanoparticles

We have developed a nanoparticle (NP) formulation for systemically delivering siRNA into metastatic tumors. The NP, composed of nucleic acids, a polycationic peptide and cationic liposome, was prepared in a self-assembling process. The NP was then modified by PEG-lipid containing a targeting ligand,...

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Hlavní autoři: Li, Shyh-Dar, Chono, Sumio, Huang, Leaf
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692667/
https://ncbi.nlm.nih.gov/pubmed/18083264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2007.11.002
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