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Development of a New Pharmacophore Model that Discriminates Active Compstatin Analogs
Compstatin and its active peptide analogs can potentially be used for therapeutic purposes because their binding to C3 prohibits its conversion into C3b, thus inhibiting complement cascades in all three complement pathways. Mallik and Morikis built three quasi-dynamic pharmacophore models for compst...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585052/ https://ncbi.nlm.nih.gov/pubmed/18844671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00709.x |
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