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Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors
Despite the use of the sirolimus (rapamycin) drug-eluting coronary stent, diabetics are at increased risk of developing in-stent restenosis for unclear reasons. Hyperleptinemia, which often coexists with diabetes and metabolic syndrome, is an independent risk factor for progression of coronary arter...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585045/ https://ncbi.nlm.nih.gov/pubmed/19020099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809743105 |
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