G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer

G0/G1 switch gene 2 (G0S2) is a direct retinoic acid target implicated in cancer biology and therapy based on frequent methylation-mediated silencing in diverse solid tumors. We recently reported that low G0S2 expression in breast cancer, particularly estrogen receptor-positive (ER+) breast cancer,...

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Pubblicato in:Cell Cycle
Autori principali: Yim, Christina Y., Bikorimana, Emmanuel, Khan, Ema, Warzecha, Joshua M., Shin, Leah, Rodriguez, Jennifer, Dmitrovsky, Ethan, Freemantle, Sarah J., Spinella, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731418/
https://ncbi.nlm.nih.gov/pubmed/28910567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1371884
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