Broad HIV-1 neutralization mediated by CD4-binding site antibodies

We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 gp120. Novel...

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Bibliografiske detaljer
Main Authors: Li, Yuxing, Migueles, Stephen A, Welcher, Brent, Svehla, Krisha, Phogat, Adhuna, Louder, Mark K, Wu, Xueling, Shaw, George M, Connors, Mark, Wyatt, Richard T, Mascola, John R
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584972/
https://ncbi.nlm.nih.gov/pubmed/17721546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1624
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