A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

Urm1 is a highly conserved ubiquitin-related modifier of unknown function. A reduction of cellular Urm1 levels causes severe cytokinesis defects in HeLa cells, resulting in the accumulation of enlarged multinucleated cells. To understand the underlying mechanism, we applied a functional proteomics a...

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Bibliographic Details
Main Authors: Schlieker, Christian D., Van der Veen, Annemarthe G., Damon, Jadyn R., Spooner, Eric, Ploegh, Hidde L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584574/
https://ncbi.nlm.nih.gov/pubmed/19017811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808756105
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