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Human P2Y(6) Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference
Combining molecular dynamics (MD) in a hydrated phospholipids (DOPC) bilayer, Monte Carlo search, and synthesis of locked nucleotide analogues we discovered that the Southern conformation of the ribose is preferred for ligand recognition by the P2Y(6) receptor. 2′-Deoxy-(S)-methanocarbaUDP was found...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583457/ https://ncbi.nlm.nih.gov/pubmed/16366591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050911p |
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