Elafin, an Elastase-specific Inhibitor, Is Cleaved by Its Cognate Enzyme Neutrophil Elastase in Sputum from Individuals with Cystic Fibrosis

Elafin is a neutrophil serine protease inhibitor expressed in lung and displaying anti-inflammatory and anti-bacterial properties. Previous studies demonstrated that some innate host defense molecules of the cystic fibrosis (CF) and chronic obstructive pulmonary disease airways are impaired due to i...

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Bibliografiske detaljer
Main Authors: Guyot, Nicolas, Butler, Marcus W., McNally, Paul, Weldon, Sinead, Greene, Catherine M., Levine, Rodney L., O'Neill, Shane J., Taggart, Clifford C., McElvaney, Noel G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583315/
https://ncbi.nlm.nih.gov/pubmed/18799464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803707200
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