Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Antzeko izenburuak

• Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors
  nork: McCoull, William, et al.
  Argitaratua: (2016)
• TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.
  nork: Hiroki Otani, et al.
  Argitaratua: (2015-01-01)
• TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells
  nork: Otani, Hiroki, et al.
  Argitaratua: (2015)
• Pharmacological profiling of a dual FAK/IGF-1R kinase inhibitor TAE226 in cellular and in vivo tumor models
  nork: Fukami, Shigemi, et al.
  Argitaratua: (2019)
• Different conformational families of pyrimidine.purine.pyrimidine triple helices depending on backbone composition.
  nork: Han, H, et al.
  Argitaratua: (1994)