Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

[Image: see text] Group I p21-activated kinase (PAK) inhibitors are indicated as important in cancer progression, but achieving high kinase selectivity has been challenging. A bis-anilino pyrimidine PAK1 inhibitor was identified and optimized through structure-based drug design to improve PAK1 poten...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: McCoull, William, Hennessy, Edward J., Blades, Kevin, Chuaqui, Claudio, Dowling, James E., Ferguson, Andrew D., Goldberg, Frederick W., Howe, Nicholas, Jones, Christopher R., Kemmitt, Paul D., Lamont, Gillian, Varnes, Jeffrey G., Ward, Richard A., Yang, Bin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2016
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150691/
https://ncbi.nlm.nih.gov/pubmed/27994749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00322
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