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Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical outcome. Recently, a novel bis-anilino pyrimidine inhibitor, TAE226, was repor...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582962/ https://ncbi.nlm.nih.gov/pubmed/19030106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003800 |
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