TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells

TAE226, a bis-anilino pyrimidine compound, has been developed as an inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor-I receptor (IGF-IR). In this study, we investigated the effect of TAE226 on non-small-cell lung cancer (NSCLC), especially focusing on the EGFR mutational statu...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Otani, Hiroki, Yamamoto, Hiromasa, Takaoka, Munenori, Sakaguchi, Masakiyo, Soh, Junichi, Jida, Masaru, Ueno, Tsuyoshi, Kubo, Takafumi, Asano, Hiroaki, Tsukuda, Kazunori, Kiura, Katsuyuki, Hatakeyama, Shinji, Kawahara, Eiji, Naomoto, Yoshio, Miyoshi, Shinichiro, Toyooka, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474554/
https://ncbi.nlm.nih.gov/pubmed/26090892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129838
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