17β-Estradiol inhibits Ca(2+)-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia

Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through both cAMP- and Ca(2+)-dependent regulation of ion and water transport. In cystic fibrosis (CF), a genetic defect causes a lack of cAMP-regulated CFTR activity, leading to diminished Cl(– )and water secretion fr...

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Autors principals: Coakley, Ray D., Sun, Hengrui, Clunes, Lucy A., Rasmussen, Julia E., Stackhouse, James R., Okada, Seiko F., Fricks, Ingrid, Young, Steven L., Tarran, Robert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582929/
https://ncbi.nlm.nih.gov/pubmed/19033671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33893
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