Defective adenosine-stimulated cAMP production in cystic fibrosis airway epithelia: a novel role for CFTR in cell signaling

Adenosine (ADO) is an extracellular signaling molecule that is an important regulator of innate lung defense. On binding ADO, the A2B receptor (A2BR) stimulates cAMP production to activate the CFTR Cl(−) channel, increase ciliary beating, and initiate cytokine secretion. We tested the hypothesis tha...

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Bibliographic Details
Main Authors: Watson, Michael J., Worthington, Erin N., Clunes, Lucy A., Rasmussen, Julia E., Jones, Lisa, Tarran, Robert
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2011
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157687/
https://ncbi.nlm.nih.gov/pubmed/21628448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-186080
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