Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator‐dependent anion and fluid secretion in airway epithelia

KEY POINTS: Raised arterial blood CO(2) (hypercapnia) is a feature of many lung diseases. CO(2) has been shown to act as a cell signalling molecule in human cells, notably by influencing the levels of cell signalling second messengers: cAMP and Ca(2+). Hypercapnia reduced cAMP‐stimulated cystic fibr...

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Veröffentlicht in:J Physiol
Hauptverfasser: Turner, Mark J., Saint‐Criq, Vinciane, Patel, Waseema, Ibrahim, Salam H., Verdon, Bernard, Ward, Christopher, Garnett, James P., Tarran, Robert, Cann, Martin J., Gray, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Molecular and Cellular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799982/
https://ncbi.nlm.nih.gov/pubmed/26574187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271309
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