Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy

The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1RKO) and compared them with cardiomyocyte-specific...

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Main Authors: Kim, Jaetaek, Wende, Adam R., Sena, Sandra, Theobald, Heather A., Soto, Jamie, Sloan, Crystal, Wayment, Benjamin E., Litwin, Sheldon E., Holzenberger, Martin, LeRoith, Derek, Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582541/
https://ncbi.nlm.nih.gov/pubmed/18801929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0265
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