Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload

Ablating insulin receptors in cardiomyocytes causes subendocardial fibrosis and left ventricular (LV) dysfunction after 4 wk of transverse aortic constriction (TAC). To determine whether these maladaptive responses are precipitated by coronary vascular dysfunction, we studied mice with cardiomyocyte...

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Detalhes bibliográficos
Main Authors: Symons, J. David, Hu, Ping, Yang, Ying, Wang, Xiaohui, Zhang, Quan-Jiang, Wende, Adam R., Sloan, Crystal L., Sena, Sandra, Abel, E. Dale, Litwin, Sheldon E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023253/
https://ncbi.nlm.nih.gov/pubmed/20971769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01200.2009
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