A Conserved Role for Phosphoinositide-3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy

Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1α and increased fatty acid oxidative (FAO) capacity. It is widely accepted that phosphoinositide-3 Kinase (PI3K) signaling to Akt1 is required for physiological cardiac growth....

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Bibliografiset tiedot
Päätekijät: O’Neill, Brian T., Kim, Jaetaek, Wende, Adam R., Theobald, Heather A., Tuinei, Joseph, Buchanan, Jonathan, Guo, Aili, Zaha, Vlad G., Davis, Don K., Schell, John C., Boudina, Sihem, Wayment, Benjamin, Litwin, Sheldon E., Shioi, Tetsuo, Izumo, Seigo, Birnbaum, Morris J., Abel, E. Dale
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084219/
https://ncbi.nlm.nih.gov/pubmed/17908558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.09.001
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