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Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines
Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against 4 different strains of P. falciparum. Many of the compounds tested showed excellent potency against chloroquine...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581884/ https://ncbi.nlm.nih.gov/pubmed/18345611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800106u |
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