4-N, 4-S & 4-O Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs. Chloroquine Resistant Malaria,

Using predictions from heme – quinoline antimalarial complex structures, previous modifications of chloroquine (CQ), and hypotheses for chloroquine resistance (CQR), we synthesize and assay CQ analogues that test structure – function principles. We vary side chain length for both monoethyl and dieth...

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Detalhes bibliográficos
Main Authors: Natarajan, Jayakumar K., Alumasa, John, Yearick, Kimberly, Ekoue-Kovi, Kekeli A., Casabianca, Leah B., de Dios, Angel C., Wolf, Christian, Roepe, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637136/
https://ncbi.nlm.nih.gov/pubmed/18512900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701478a
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