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Setting the chaperonin timer: The effects of K(+) and substrate protein on ATP hydrolysis
The effects of potassium ion on the nested allostery of GroEL are due to increases in the affinity for nucleotide. Both positive allosteric transitions, TT-TR and TR-RR, occur at lower [ATP] as [K(+)] is increased. Negative cooperativity in the double-ringed system is also due to an increase in the...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580752/ https://ncbi.nlm.nih.gov/pubmed/18988745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807429105 |
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