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Setting the chaperonin timer: The effects of K(+) and substrate protein on ATP hydrolysis

The effects of potassium ion on the nested allostery of GroEL are due to increases in the affinity for nucleotide. Both positive allosteric transitions, TT-TR and TR-RR, occur at lower [ATP] as [K(+)] is increased. Negative cooperativity in the double-ringed system is also due to an increase in the...

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Main Authors: Grason, John P., Gresham, Jennifer S., Widjaja, Lusiana, Wehri, Sarah C., Lorimer, George H.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580752/
https://ncbi.nlm.nih.gov/pubmed/18988745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807429105
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