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Setting the chaperonin timer: A two-stroke, two-speed, protein machine
In a study of the timing mechanism of the chaperonin nanomachine we show that the hemicycle time (HCT) is determined by the mean residence time (MRT) of GroES on the cis ring of GroEL. In turn, this is governed by allosteric interactions within the trans ring of GroEL. Ligands that enhance the R (re...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580751/ https://ncbi.nlm.nih.gov/pubmed/18988739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807418105 |
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