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Setting the chaperonin timer: A two-stroke, two-speed, protein machine
In a study of the timing mechanism of the chaperonin nanomachine we show that the hemicycle time (HCT) is determined by the mean residence time (MRT) of GroES on the cis ring of GroEL. In turn, this is governed by allosteric interactions within the trans ring of GroEL. Ligands that enhance the R (re...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580751/ https://ncbi.nlm.nih.gov/pubmed/18988739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807418105 |
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