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Substrate protein switches GroE chaperonins from asymmetric to symmetric cycling by catalyzing nucleotide exchange
The complex kinetics of Pi and ADP release by the chaperonin GroEL/GroES is influenced by the presence of unfolded substrate protein (SP). Without SP, the kinetics of Pi release are described by four phases: a “lag,” a “burst” of ATP hydrolysis by the nascent cis ring, a “delay” caused by ADP releas...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3831975/ https://ncbi.nlm.nih.gov/pubmed/24167257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317702110 |
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