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Setting the chaperonin timer: A two-stroke, two-speed, protein machine

In a study of the timing mechanism of the chaperonin nanomachine we show that the hemicycle time (HCT) is determined by the mean residence time (MRT) of GroES on the cis ring of GroEL. In turn, this is governed by allosteric interactions within the trans ring of GroEL. Ligands that enhance the R (re...

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Sonraí Bibleagrafaíochta
Main Authors: Grason, John P., Gresham, Jennifer S., Lorimer, George H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580751/
https://ncbi.nlm.nih.gov/pubmed/18988739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807418105
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