Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

BACKGROUND AND PURPOSE: Amiodarone (2-n-butyl-3-[3,5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran, B2-O-CH(2)CH(2)-N-diethyl) is an effective class III antiarrhythmic drug demonstrating potentially life-threatening organ toxicity. The principal aim of the study was to find amiodarone analogues tha...

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Main Authors: Waldhauser, K M, Brecht, K, Hebeisen, S, Ha, H R, Konrad, D, Bur, D, Krähenbühl, S
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579668/
https://ncbi.nlm.nih.gov/pubmed/18604229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.287
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