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Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues
BACKGROUND AND PURPOSE: Amiodarone (2-n-butyl-3-[3,5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran, B2-O-CH(2)CH(2)-N-diethyl) is an effective class III antiarrhythmic drug demonstrating potentially life-threatening organ toxicity. The principal aim of the study was to find amiodarone analogues tha...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579668/ https://ncbi.nlm.nih.gov/pubmed/18604229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.287 |
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