Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice

Urokinase-type plasminogen activator (uPA) is expressed at elevated levels in atherosclerotic human arteries, primarily in macrophages. Plasminogen (Plg), the primary physiologic substrate of uPA, is present at significant levels in blood and interstitial fluid. Both uPA and Plg have activities that...

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Hlavní autoři: Kremen, Michal, Krishnan, Ranjini, Emery, Isaac, Hu, Jie Hong, Slezicki, Katherine I., Wu, Alyssa, Qian, Kun, Du, Liang, Plawman, Abigail, Stempien-Otero, April, Dichek, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579386/
https://ncbi.nlm.nih.gov/pubmed/18957535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808650105
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