Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice

Urokinase-type plasminogen activator (uPA) is expressed at elevated levels in atherosclerotic human arteries, primarily in macrophages. Plasminogen (Plg), the primary physiologic substrate of uPA, is present at significant levels in blood and interstitial fluid. Both uPA and Plg have activities that...

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Detalhes bibliográficos
Main Authors: Kremen, Michal, Krishnan, Ranjini, Emery, Isaac, Hu, Jie Hong, Slezicki, Katherine I., Wu, Alyssa, Qian, Kun, Du, Liang, Plawman, Abigail, Stempien-Otero, April, Dichek, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579386/
https://ncbi.nlm.nih.gov/pubmed/18957535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808650105
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