The Level of Macrophage uPA Expression is an Important Determinant of Atherosclerotic Lesion Growth in Apoe(−/−) Mice

OBJECTIVE: Enhanced plasminogen activation, mediated by overexpression of urokinase-type plasminogen activator (uPA), accelerates atherosclerosis in apolipoprotein E-null mice. However, the mechanisms through which uPA acts remain unclear. In addition, although elevated uPA expression can accelerate...

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Detalhes bibliográficos
Main Authors: Krishnan, Ranjini, Kremen, Michal, Hu, Jie Hong, Emery, Isaac, Farris, Stephen D., Slezicki, Katherine I., Chu, Talyn, Du, Liang, Dichek, Helén L., Dichek, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766014/
https://ncbi.nlm.nih.gov/pubmed/19729604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.195529
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